Publications
The Werner Lab at the University of Utah (Salt Lake City, UT)
2024
Audrey L Brown, Adriaan B Meiborg, Mirita Franz-Wachtel, Boris Macek, Spencer Gordon, Ofer Rog, Cameron J Weadick, Michael S Werner, Characterization of the Pristionchus pacificus “epigenetic toolkit” reveals the evolutionary loss of the histone methyltransferase complex PRC2, Genetics, 2024;, iyae041
Jung Julie, Loschko Tobias, Reich Shelley, Rassoul-Agha Maxim and Werner Michael S. 2024. Newly identified nematodes from the Great Salt Lake are associated with microbialites and specially adapted to hypersaline conditions. Proc. R. Soc. B.2912023265320232653
Featured in:
NBC: https://www.nbcnews.com/now/video/scientists-in-utah-discover-new-species-of-roundworms-206881349600
Newsweek: https://www.newsweek.com/strange-critters-great-salt-lake-1879339
The Salt Lake Tribune: https://www.sltrib.com/news/environment/2024/03/13/new-critters-found-living-water/
Michael's Post-doc with Ralf J. Sommer at The Max Planck Institute for Developmental Biology (Tübingen, Germany)
Werner, M.S., Loschko, T., King, T. et al. Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form. Nat Commun 14, 2095 (2023). https://doi.org/10.1038/s41467-023-37734-z
Renahan, T.S., Lo, W.S., Werner, M.S., Rochat, J., Herrmann, M., Sommer, R.J. (2021) Nematode biphasic “boom and bust” dynamics are dependent on host bacterial load while linking dauer and mouth-form polyphenisms. Environmental Microbiology. doi:10.1111/1462-2920.15438.
Theska T, Sieriebriennikov B, Wighard SS, Werner MS*, Sommer RJ*. (2020). Geometric Morphometrics of Microscopic Animals as Exemplified by Model Nematodes. Nature Protocols. 10.1038/s41596-020-0347-z. (*co-corresponding author)
Werner, M.S.*, Claaßen, M.H.*, Renahan, T.*, Dardiry, M., and Sommer, R.J. (2018). Adult Influence on Juvenile Phenotypes by Stage-Specific Pheromone Production. iScience 10, 123–134. (*co-first author)
Werner, M.S., Sieriebriennikov, B., Prabh, N., Loschko, T., Lanz, C., and Sommer, R.J. (2018). Young genes have distinct gene structure, epigenetic profiles, and transcriptional regulation. Genome Res. 28, 1675–1687. https://genome.cshlp.org/content/28/11/1675.full.html
Werner, M.S., Sieriebriennikov, B., Loschko, T., Namdeo, S., Lenuzzi, M., Dardiry, M., Renahan, T., Sharma, D.R., and Sommer, R.J. (2017). Environmental influence on Pristionchus pacificus mouth form through different culture methods. Sci. Rep. 7, 7207.
Sommer, R.J., Dardiry, M., Lenuzzi, M., Namdeo, S., Renahan, T., Sieriebriennikov, B., and Werner, M.S. (2017). The genetics of phenotypic plasticity in nematode feeding structures. Open Biol. 7.
Michael's PhD with Alex J. Ruthenburg at the University of Chicago (Chicago, IL)
Gupta, A., Xu, J., Lee, S., Tsai, S.T., Zhou, B., Kurosawa, K., Werner, M.S., Koide, A., Ruthenburg, A.J., Dou, Y., et al. (2018). Facile target validation in an animal model with intracellularly expressed monobodies. Nature Chemical Biology 14, 895–900.
Werner, M.S., Sullivan, M.A., Shah, R.N., Nadadur, R.D., Grzybowski, A.T., Galat, V., Moskowitz, I.P., and Ruthenburg, A.J. (2017). Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription. Nat. Struct. Mol. Biol. 24, 596–603.
*Corresponding highlight in NSMB: Gayen & Kalantry, Chromatin-enriched lncRNAs: a novel class of enhancer RNAs
Yang, X.H., Nadadur, R.D., Hilvering, C.R., Bianchi, V., Werner, M., Mazurek, S.R., Gadek, M., Shen, K.M., Goldman, J.A., Tyan, L., et al. (2017). Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm. Elife 6.
Werner, M.S., and Ruthenburg, A.J. (2015). Nuclear Fractionation Reveals Thousands of Chromatin-Tethered Noncoding RNAs Adjacent to Active Genes. Cell Rep. 12, 1089–1098.
*faculty 1000 recommendation
Werner, M., and Ruthenburg, A.J. (2011). The United States of Histone Ubiquitylation and Methylation. Molecular Cell 43, 5–7.